Astros vs Guardians Picks and Prediction – 6/6/2025

The Houston Astros open a three-game series on the road Friday versus the Cleveland Guardians. Houston dropped to 33-28 following Wednesday’s 3-0 loss to the Pittsburgh Pirates. The loss snapped a two-game winning streak for the Astros. Houston is leading the American League West by a half-game over the Seattle Mariners. Keep up to date with all the MLB action with our MLB predictions.

Jeremey Pena is batting .312 with 72 hits and a .374 on-base percentage to lead the Astros in the three categories. Isaac Paredes is the leader in home runs with 12 and in RBI with 34. Houston is batting .251 with a .389 slugging percentage. On Friday, the Houston Astros will send Colton Gordon to the mound. The left-hander is 0-1 with a 5.95 ERA, 20 Ks, and 3 BBs.

The Cleveland Guardians improved to 33-27 following Wednesday’s 4-0 victory over the New York Yankees. Angel Martinez hit a two-run homer for Cleveland, and Luis Ortiz was victorious for the first time since April 18. Cleveland has won three of the last four. The Guardians are third in the American League Central, 6 ½ games behind the first-place Detroit Tigers.

Jose Ramirez is batting .327 with 11 home runs, 72 hits, and an on-base percentage of .382 to lead Cleveland in the four categories. Carlos Santana is the leader in RBI with 29. Cleveland is batting .236 with a .381 slugging percentage. The Cleveland Guardians have not announced a starting pitcher for Friday's first game of a three-game series at home versus the Houston Astros.

The Cleveland Guardians will win on Friday when opening a three-game series at home versus the Houston Astros. Cleveland has won four of its last six, and the Guardians have won 10 of the last 15 played during June. Houston starter Colton Gordon has struggled in each of his four appearances, allowing 13 runs on 24 hits across 19.2 innings. Final Score Prediction: Cleveland Guardians win 5-3.