Astros vs White Sox Picks and Prediction – 5/4/2025

The Houston Astros complete a three-game series on the road Sunday versus the Chicago White Sox. Houston is 16-15 following its 7-3 loss to Chicago on Friday in the opening game of the series. Houston has lost two straight, and the Astros are third in the American League West, trailing the first-place Seattle Mariners by three games and the Athletics by one game. Keep up to date with all the MLB action with our expert MLB picks.

Jeremy Pena is batting .278 to lead Houston. Jose Altuve is the leader in home runs with four and hits with 33, while Yordan Alvarez is the leader in RBI with 18. Isaac Paredes is the leader in on-base percentage at .358. Houston is batting .238 with a .359 slugging percentage. On Sunday, Houston will send Lance McCullers Jr to the mound. The left-hander will be making his season debut for the Astros.

The Chicago White Sox improved to 9-23 following Friday’s four-run victory over Houston. Chicago has won consecutive games at home for the second time in 2025. Luis Robert Jr hit a home run for the White Sox, and Edgar Quero had two hits and a pair of RBI. Chicago is last in the American League Central, 11 ½ games behind the first-place Detroit Tigers.

Lenyn Sosa is batting .261 with 29 hits to lead Chicago in both categories. Andrew Benintendi is the leader in home runs with five. Luis Robert Jr is the leader in RBI with 14 and on-base percentage at .310. Chicago is batting .216 with a .333 slugging percentage. On Sunday, Chicago will send Bryse Wilson to the mound. The right-hander is 0-1 with a 5.00 ERA, 11 Ks, and 9 BBs.

Chicago has lost 13 of its last 18, and the White Sox have lost six of the last eight played at home. Houston starter Lance McCullers Jr will be making his season debut after opening the season on the injured list. Chicago starter Bryse Wilson is coming off a poor outing in which the right-hander allowed three runs on two hits across 3.1 innings of relief work. Final Score Prediction: Houston Astros win 5-3.