Tigers vs Brewers Picks and Prediction – 4/16/2025

In Wednesday afternoon MLB interleague action, the Detroit Tigers will square off against the Milwaukee Brewers from American Family Field. Be ready for the baseball season with all of our MLB predictions. The Tigers (10-7) are a game below .500 on the road and are sitting atop the AL Central Division standings. Last night, Detroit SP Jack Flaherty (1-1) gave up three runs in four plus innings during a 5-0 road loss against Milwaukee. 

Twenty-five year old righty Reese Olson (1-1 6.00 ERA) will take the mound for the Tigers in this matchup. Last time out, Olson (4.1 IP) gave up six hits and four runs during a 7-6 road victory against Minnesota. 

The Milwaukee Brewers have won six of their first nine home games and are 1.5 games off the pace in the NL Central Division race. On Tuesday, 1B Rhys Hoskins went 3-for-4 with a home run and a pair of RBIs to spark the Milwaukee offense. SP Quinn Priester (1-0) allowed one hit across five shutout frames to earn the win for the Brewers (9-9) 

The Brewers will counter with veteran left-hander Jose Quintana (1-0 0.00 ERA) in the series finale. In his first start of the year, Quintana allowed just four hits across seven shutout frames during a 7-0 road victory against Arizona.  

Detroit OF Parker Meadows (arm) has resumed his hitting program and plans to return to the lineup later next month. Through 17 games, Detroit ranks 9th in OPS and 8th in runs scored. For the regular season, Milwaukee ranks 16th in OPS and 6th in runs scored. Take the under. Final Score Prediction, Milwaukee Brewers win 4-2.