Tigers vs Angels Picks and Prediction – 5/4/2025

This Saturday, Jack Flaherty and the Detroit Tigers take on Kyle Hendricks and the Los Angeles Angels at Comerica Park to open a weekend series. Get our free MLB Picks all season long! The Tigers, now 20-12, are coming off a dominant 10-4 win over the Angels on Thursday, continuing their strong start behind consistent pitching and timely hitting.

Flaherty has been in command this season, showing the velocity and control that made him a frontline starter in previous years. He’ll look to set the tone early and challenge an Angels lineup that has been inconsistent and prone to long scoring droughts during their recent skid.

The Angels, sitting at 12-18, are reeling after Thursday’s loss and turn to veteran Kyle Hendricks to stop the bleeding. Hendricks will need to rely on location and soft contact, as his margin for error is slim against a Tigers lineup that’s finding its rhythm at the plate.

Detroit’s keys will be continuing their aggressive offensive approach and giving Flaherty early support. The Angels must play clean defense and give Hendricks room to maneuver through the Tigers’ top hitters if they want to stay competitive in the series opener.

With Flaherty commanding the zone and Detroit swinging hot bats, the Tigers should remain in control. Hendricks may keep it close early, but Detroit’s momentum and execution across the board give them the edge at home. Take the Tigers to win this game by a nice margin. Final Score Prediction, Detroit Tigers win 5-2.