Tigers vs Guardians Picks and Prediction – 7/4/2025

The Detroit Tigers open a three-game series on the road Friday versus the Cleveland Guardians. Detroit is 54-33 following its 9-4 loss to the Washington Nationals on Wednesday, in the second game of a doubleheader after winning the opener 11-2. Detroit leads the American League Central by 12 ½ games over the Minnesota Twins and has the best record in the AL. Keep up to date with all the MLB action with our expert MLB picks.

Riley Greene is batting .296 with 21 home runs, 69 RBI, and 97 hits to lead Detroit in the four categories. Gleyber Torres is the leader in on-base percentage at .383. Detroit is batting .257 with a .430 slugging percentage. Detroit has not announced its starting pitcher for the opening game of a three-game series on the road versus American League Central rival Cleveland.

The Cleveland Guardians dropped to 40-44 following Wednesday’s 5-4 loss to the Chicago Cubs. Cleveland has lost the first two games of its three-game series versus Chicago, which concludes on Thursday. The Guardians have lost six straight and trail first-place Detroit in the AL Central by 12 ½ games, which is tied for second with the Minnesota Twins.

Jose Ramirez is batting .301 with 13 home runs, 92 hits, and an on-base percentage of .362 to lead Cleveland in each of the four categories. Carlos Santana leads in RBI with 38. Cleveland is batting .225 with a .365 slugging percentage. On Friday, Cleveland will send Slade Cecconi to the mound. The right-hander is 3-3 with a 3.64 ERA, 42 Ks, and 14 BBs.

While the OVER has cashed more often than not of late for Detroit, the play here is UNDER. The UNDER has cashed in 11 of Cleveland's last 15. These two American League Central rivals played a four-game series in late May, with three of the four games cashing UNDER. Cleveland starter Slade Cecconi has had five consecutive solid outings, allowing eight runs on 26 hits across 26.2 innings. Final Score Prediction: Detroit Tigers win, but our best play is UNDER 5-2.