Tigers vs White Sox Picks and Prediction – 6/5/2025

AL Central Division rivals will square off on Thursday afternoon, when the Detroit Tigers and the Chicago White Sox wrap up their series from Rate Field. Be ready for the baseball season with all of our MLB predictions. The Tigers (41-22) have won 20 of their first 34 road games and own the best overall record in the American League. Last night, OF Riley Greene went 3-for-5 with two RBIs and a run scored to spark Detroit to a 5-4 road victory. 

2018 number one overall draft pick Casey Mize (6-1 2.82 ERA) will take the mound for the Tigers in this matchup. In his last start, Mize (3.1 IP) gave up eight hits and three runs during a 7-5 road victory against Kansas City. 

The Chicago White Sox are four games below .500 at home and own the worst overall record in the American League. During Wednesday’s home loss, Chase Meidroth collected three of Chicago’s seven hits and drove in a run. Jared Shuster surrendered four runs in the opener’s role and did not factor in the decision for the White Sox, who fell to 19-43 overall.

Chicago manager Will Venable will turn to right-hander Sean Burke (3-6 4.20 ERA) on Thursday. Last time out, Burke (6 IP) allowed two runs and retired six batters by strikes during a 2-1 road loss against Baltimore. 

Detroit rookie SP Jackson Jobe has landed on the 15-day injured list with a right elbow flexor strain. Through 63 games, Detroit ranks 9th in OPS and 4th in runs scored. For the season, Chicago ranks 29th in OPS and 26th in runs scored. Take the White Sox to win at home. Final Score Prediction, Chicago White Sox win 5-3.