Tigers vs White Sox Picks and Prediction – 6/4/2025

Detroit comes into this one with a 40-21 record and is rolling after a 13-1 demolition of the White Sox on Monday. The Tigers have taken the first four games of the season series and look to keep dominating behind Casey Mize, who’s 6-1 with a 2.82 ERA. Chicago sits at a dismal 18-42 and is throwing Sean Burke, who’s 3-6 with a 4.20 ERA and a 1.42 WHIP. Game’s at 5:40 PM EST from Rate Field. Elevate your MLB game with our top-notch MLB picks.

Detroit has won four of its last five and is performing well at the plate, on the mound, and in the field. Mize went six innings strong in his last outing and gives the Tigers consistency on the mound. Offensively, the bats are delivering, and Spencer Torkelson just keeps raking, already with 14 homers and 42 RBIs. The top of the order has been productive, and they’ve already lit up Burke once this year.

On the mound, the Tigers rank among the league’s best with a 3.13 ERA and 1.15 WHIP. Opponents are only hitting .226 off Detroit arms, and the bullpen has held leads well. Despite some injuries to the pitching staff, the depth has held strong. With Mize on the hill and the Sox lineup struggling, Detroit looks primed to keep things rolling.

Chicago is trending the opposite way, losers of four straight, including getting smacked by the Tigers 13-1 last time out. The lineup has been ice cold, scoring just eight runs in the last four games. Miguel Vargas leads with 26 RBIs and eight home runs, but there isn’t much help around him. The team looks lost at the plate and unable to string anything together.

On the mound, Chicago’s 4.25 ERA and 1.38 WHIP are signs of overall struggles. Opposing hitters are posting a .248 average, and Burke’s command issues—31 walks in 60 innings—have been costly. The bullpen hasn’t been able to shut the door either. Even at home, the White Sox look overwhelmed and outclassed by a team that’s beaten them every way possible this season.

This one’s been a mismatch all year. Detroit’s 4-0 against the Sox, outscoring them 37-7 in those games. Mize has been sharp and consistent, and the offense is locked in. Chicago can’t hit, can’t pitch, and Burke’s control issues won’t help. Tigers keep cruising. Final Score Prediction: Detroit Tigers win 7-2.