Rockies vs Padres Picks and Prediction – 4/12/2025

The San Diego Padres (10–3) return to Petco Park on Friday to host the struggling Colorado Rockies (3–9) in the opener of a three-game NL West series. First pitch is scheduled for 9:40 PM ET. Get in on the action with our free MLB picks.

The Rockies have endured a tough start to the season, holding a 3–9 record. Their pitching staff has struggled, with a team ERA of 5.16, ranking 28th in the league. However, they have been proficient in limiting walks, ranking fourth in fewest walks allowed. ​German Márquez (0–1, 2.45 ERA) will start for Colorado. Historically, Márquez has performed well against the Padres, holding a 10–3 record with a 4.38 ERA in 18 career games, including a 3.64 ERA in 10 games at Petco Park. ​Offensively, Ryan McMahon has been a bright spot, aiming to extend his hot streak. He has hit four career home runs at Petco Park. ​

The Padres have started the season strong, boasting a 10–3 record. They return home after a six-game road trip, ready to face their first NL West opponent of the season. ​Nick Pivetta (1–1, 2.70 ERA) will take the mound for San Diego. Pivetta aims to replicate his dominant form from his first 2025 start, where he pitched seven scoreless innings. ​The Padres' offense has been consistent, contributing to their early success. They have a strong home record, going 7–0 at Petco Park this season. 

The Padres have been rolling, for the most part, in 2025. On the other side, Colorado looks to be firmly in the cellar of the MLB. Even as large favorites, San Diego is the clear side, and we will take the run line to get the most value out of our Padres bet. Padres win 6-2.