Rockies vs Cubs Picks and Prediction – 5/26/2025

Historic Wrigley Field will play host to a Memorial Day MLB clash between the Colorado Rockies and the Chicago Cubs. Be ready for the baseball season with all of our MLB predictions. The Rockies have dropped 22 of their first 25 road games and rank last in the majors with a 5.75 ERA. Colorado C Hunter Goodman leads the club in batting average (.275), hits (52), and RBIs (31). 

Rookie left-hander Carson Palmquist (0-2 11.88 ERA) will make his third career major league start for the Rockies. In his last start, Palmquist (4.1 IP) was roughed up for ten hits and seven runs (6 ER) during a 9-5 home loss versus Philadelphia. 

The Chicago Cubs have won 15 of their first 25 home games and hold a two-game lead over St. Louis for first place in the NL Central Division. On Sunday, OF Seiya Suzuki crushed a three-run blast in the eighth inning to lift Chicago to an 11-8 road victory against Cincinnati. C Reese McGuire added two solo shots for the Cubs, who improved to 32-21 overall. 

Thirty-three year old righty Jameson Taillon (3-3 4.13 ERA) will head to the hill for the Cubs in this contest. Last time out, Taillon lasted seven innings and allowed just one run during a 14-1 road triumph against Miami. 

Chicago SP Shota Imanaga (hamstring) will throw a bullpen session on Tuesday and hopes to rejoin the rotation next month. Through 53 games, Colorado ranks 28th in OPS and 29th in runs scored. For the season, Chicago ranks 3rd in OPS and 1st in runs scored. Take the Rockies to win on the road. Final Score Prediction, Colorado Rockies win 5-3.