Rockies vs Cubs Picks and Prediction – 5/28/2025

By: David Anicetti |

Last Updated: 05/26/2025 at 9:39 PM ET

Colorado Rockies at Chicago Cubs 05/27/25 - MLB Picks & Predictions
Game Start: 5/28/2025, 12:05 AM UTC
Latest Odds: CHC -325 ; O/U 8

Rockies vs Cubs Prediction

On Tuesday, the Colorado Rockies will play the second game of a three-game series on the road in the Windy City versus the Chicago Cubs. Colorado is 9-44 following its 5-4 loss to the New York Yankees on Sunday. Colorado lost two out of three to the Yankees, and the Rockies have dropped seven of the last eight. Colorado trails the first-place Los Angeles Dodgers in the National League West by 23 games. Keep up to date with all the MLB action with our expert MLB picks.

Hunter Goodman is batting .275 with 31 RBI and 53 hits to lead Colorado in the three categories. Jordan Beck is the leader in home runs with eight, and Ryan McMahon is the leader in on-base percentage at .335. Colorado is batting .220 with a .361 slugging percentage. On Tuesday, the Rockies will send German Marquez to the mound. The right-hander is 1-7 with a 7.66 ERA, 26 Ks, and 18 BBs.

The Chicago Cubs improved to 32-21 following Sunday’s 11-8 victory over the Cincinnati Reds. Pete Crow-Armstrong hit a grand slam to put Chicago ahead for good. Crow-Armstrong had six RBI in Sunday’s win. The Cubs have won four of the last five, and Chicago leads the National League Central by two games over the second-place St Louis Cardinals.

Nico Hoerner is batting .294 to lead Chicago. Seiya Suzuki is the leader in home runs with 14 and RBI with 49, while Pete Crow-Armstrong is the leader in hits with 60. Kyle Tucker is the leader in on-base percentage at .384. Chicago is batting .264 with a .459 slugging percentage. On Tuesday, Chicago will send Cade Horton to the mound. The right-hander is 2-0 with a 4.40 ERA, 10 Ks, and 3 BBs.

Rockies vs Cubs Pick Analysis

Chicago will win at home on Tuesday when hosting Colorado, but the play here is OVER. The OVER has cashed in six of Chicago's last seven, and four of Chicago's last five head-to-head versus Colorado. Colorado starter German Marquez is coming off a strong outing after allowing one run on four hits across seven innings. Chicago starter Cade Horton has allowed six runs across 14.1 innings in three outings. Final Score Prediction: Chicago Cubs win but our best play is OVER 8-3.

Our Free MLB Pick for Chicago Cubs vs Colorado Rockies

Over 8