Cleveland Indians at Chicago White Sox 9/21/22 - MLB Picks & Predictions

The Cleveland Guardians play the second game of a three-game series on the road Wednesday against the Chicago White Sox. Cleveland improved to 80-67 following its 11-4 victory over the Minnesota Twins on Monday. Josh Naylor and Amed Rosario each belted a three-run homer. Cleveland leads the American League Central  by four games over the Chicago White Sox. Stay on top of the baseball world with our free baseball picks. 

Andres Gimenez is batting .298 to lead Cleveland, while Amed Rosario is the leader in hits with 165. Third baseman Jose Ramirez is the leader in home runs with 28 and RBIs with 113. Steven Kwan is the leader in on-base percentage at .370. On Wednesday, the Cleveland Guardians will send Triston McKenzie to the mound. The right-hander is 10-11 with a 3.08 ERA, 167 Ks and 43 BBs.

The Chicago White Sox improved to 76-71 following an 11-5 victory over the Detroit Tigers on Sunday. Chicago has won two straight and four of the last six. The White Sox are second in the American League Central, four games behind first place. Chicago is fifth in the AL wildcard race, 5 ½ games behind the third and final spot currently held by Seattle.

First baseman Jose Abreu is batting .309 to lead Chicago and has team highs in hits with 172 and on-base percentage at .383. Right fielder Andrew Vaughn is the leader in home runs with 17 and RBIs with 73. On Wednesday, the Chicago White Sox will send Lance Lynn to the mound. The right-hander is 7-5 with a 3.99 ERA, 113 Ks and 16 BBs.