Guardians vs Nationals Picks and Prediction – 5/7/2025

The Wednesday MLB schedule will get underway with a matinee between the Cleveland Guardians and the Washington Nationals from Nationals Park. Be ready for the baseball season with all of our MLB predictions. The Guardians (21-15) have split their first 20 road games and trail AL Central Division leading Detroit by 1.5 games. In the second game of Tuesday’s doubleheader, 1B Carlos Santana’s three-run blast was all the offense Cleveland would need during a 9-1 road victory against Washington. 

Twenty-six year old righty Logan Allen (1-2 4.02 ERA) will make his seventh start of the year for the Guardians. In his previous two outings, Allen has been tagged for 15 hits and ten runs across ten frames.

The Washington Nationals are two games above .500 at home and are 6.5 games off the pace in the NL East Division race. 3B Jose Tena delivered a go-ahead two-run double in the seventh inning to lift Washington to a 10-9 home victory versus Cleveland. DH James Wood added a two-run blast for the Nationals (17-20).

Washington manager Dave Martinez will turn to left-hander Mitchell Parker (3-2 3.48 ERA) on Wednesday. In his last start, Parker (4 IP) walked four batters and gave up five runs during a 6-1 road loss against Cincinnati. 

Washington 3B Paul DeJong is recovering from nose surgery and is not expected to return until July. Through 36 games, Cleveland ranks 19th in OPS and 21st in runs scored. For the season, Washington ranks 15th in OPS and 15th in runs scored. Take the Nationals to win at home. Final Score Prediction, Washington Nationals win 4-3.