Guardians vs Blue Jays Picks and Prediction – 5/4/2025

By: David Anicetti |

Last Updated: 05/03/2025 at 8:55 PM ET

Cleveland Guardians at Toronto Blue Jays 05/04/25 - MLB Picks & Predictions
Game Start: 5/4/2025, 5:37 PM UTC
Latest Odds: TOR -118 ; O/U 8

Guardians vs Blue Jays Prediction

The Cleveland Guardians complete a three-game series on the road Sunday versus the Toronto Blue Jays. Cleveland is 18-14 following its 5-3 loss to Toronto in the opening game of the series on Friday. Cleveland had its three-game winning streak snapped by the loss on Friday. The Guardians are second in the American League Central, 2 ½ games behind the first-place Detroit Tigers. Keep up to date with all the MLB action with our expert MLB picks.

Steven Kwan is batting .323 with 41 hits and an on-base percentage of .372 to lead Cleveland in the three categories. Kyle Manzardo is the leader in home runs with eight and RBI with 20. Cleveland is batting .233 with a .382 slugging percentage. On Sunday, Cleveland will send Tanner Bibee to the mound. The right-hander is 2-2 with a 4.36 ERA, 25 Ks, and 14 BBs.

The Toronto Blue Jays improved to 16-16 following Friday’s two-run victory over Cleveland. Nathan Lukes hit an eighth-inning two-run single with two outs to snap a tie game and help lead the Blue Jays to the victory. Toronto has won three straight. The Blue Jays are third in the American League East, three games behind the first-place New York Yankees.

George Springer is batting .314 with an on-base percentage of .423 to lead Toronto in both categories. Vladimir Guerrero Jr is the leader in home runs with four and RBI with 17, while Bo Bichette is the leader in hits with 39. Toronto is batting .238 with a .351 slugging percentage. On Sunday, Toronto will send Bowden Francis to the mound. The right-hander is 2-4 with a 5.28 ERA, 23 Ks, and 9 BBs.

Guardians vs Blue Jays Pick Analysis

Cleveland will win on the road behind strong pitching on Sunday. Toronto has lost eight of its last 12 overall and will have problems against the Guardians’ starting pitcher. Cleveland starter Tanner Bibee has had two consecutive strong outings, allowing three runs on 10 hits across 13 innings. Toronto starter Bowden Francis has been hit hard in two straight outings, allowing 10 runs on 16 hits across 7.2 innings. Final Score Prediction: Cleveland Guardians win 5-2.

Our Free MLB Pick for Toronto Blue Jays vs Cleveland Guardians

Cleveland Guardians -105