Guardians vs Mariners Picks and Prediction – 6/15/2025

Cleveland is looking to bounce back after getting crushed 7-2 by Seattle on Friday night. The Guardians come in at 35-33 overall and 16-18 on the road. Luis Ortiz (3-7, 4.26 ERA) will take the mound against Seattle’s Emerson Hancock (2-2, 5.04 ERA). The Mariners sit at 34-34 and are even at home (17-17), hoping to string together back-to-back wins. Elevate your MLB game with our top-notch MLB picks.

The Guardians got lit up in the series opener, allowing 7 runs while managing just 2 themselves. They've dropped three of the last four and haven’t looked sharp at the plate. Jose Ramirez continues to be the bright spot with a .327 average, 12 homers, and 33 RBI, but outside of him, Cleveland's offense has been inconsistent and lacking pop. Santana adds 34 RBI with 8 long balls, but is hitting just .251.

On the mound, Cleveland owns a 3.95 ERA and 1.38 WHIP. The pitching staff is banged up, missing arms like Paul Sewald, Shane Bieber, and Trevor Stephan. Ortiz has had control issues, walking 34 over 69.2 innings while giving up 9 homers. Despite striking out 76, his 1.45 WHIP shows how much traffic he allows. The Guardians also struggle offensively overall, with a weak .233 team average, .306 OBP, and 71 home runs on the year.

Seattle got a needed jolt with the series-opening win, powered by 26-homer man Cal Raleigh, who also leads with 53 RBI. J.P. Crawford is getting on base at a .399 clip while hitting .286. Despite a recent three-game skid in Arizona, the Mariners are back home where they’ve played solid .500 ball and look to add wins.

The Mariners carry a 4.03 ERA and a better 1.32 WHIP. Hancock, however, hasn’t impressed much, with 63 hits and 10 homers allowed in 55.1 innings. Still, the Mariners’ pitching has walked fewer hitters (212) and limited damage more effectively than Cleveland’s. Offensively, Seattle outpaces Cleveland with a .244 team average, 89 homers, and a stronger .322 OBP and .401 slugging percentage.

Seattle holds the edge at the plate, slugging more homers (89 to 71), and boasting better OBP, average, and slugging percentage. Raleigh is a real problem for Cleveland’s weakened pitching staff, and Hancock’s issues may still be less damaging than what Ortiz has shown. Add in the Guardians' injuries on the mound and Seattle being at home, and the Mariners should get it done. Final Score Prediction: Mariners win 6-4.