Guardians vs Padres Picks and Prediction – 4/2/2025

The Cleveland Guardians remain in San Diego on Wednesday to take on the Padres. The Guardians are averaging 4.5 runs scored per game with 8.5 hits. Cleveland won their first series of the season against the Royals. The Guardians outscored the Royals 16-10. Stay up to date with our expert's MLB Picks. 

Ben Lively will make his 2nd start on the mound for the Cleveland Guardians. Lively pitched 5 innings in his first start. Lively allowed 3 earned runs and had 3 strikeouts. Lively went 13-10 for Cleveland last season and posted a 5.40 ERA .

The San Diego Padres swept the Atlanta Braves in their first series of the season. The Padres scored 17 runs through four games. San Diego is averaging 4.8 runs scored per game with 9 hits. The Padres scored 7 runs on Monday when they beat the Guardians in the first game of this series. 

Dylan Cease will make his 2nd start of the season for the San Diego Padres. Cease pitched 4.1 innings in his first start. Cease had 7 strikeouts and allowed 3 earned runs. Cease went 14-11 with San Diego last season and posted a 6.23 ERA. 

The San Diego Padres have been one of the hottest teams to start the season. The Padres are heavy home favorites on Wednesday and for good reason. The Padres have the home field and the starting pitching advantage in this matchup. The value is in the total. Final Score Prediction, San Diego Padres win, but the play is on the OVER 6-3.