Guardians vs Athletics Picks and Prediction – 6/22/2025

This Saturday, Logan Allen takes the mound for Cleveland against Mitch Spence and the Athletics. Get our free MLB Picks all season long! The Guardians are coming off a tough 2-1 loss to the Giants, while Oakland enters this matchup riding momentum after a 6-4 win over the Astros. First pitch is set for Friday night at Progressive Field.

Allen has had an up-and-down season, but he remains a key part of Cleveland’s rotation. His fastball-slider combo can be effective when he gets ahead in counts. The Guardians’ offense, while not overly powerful, has found ways to scratch runs across with timely hitting and aggressive baserunning.

Mitch Spence continues to make strides for the Athletics. His command was solid in his last outing, and he’ll look to build on that performance. The A’s have been inconsistent at the plate, but players like Brent Rooker and JJ Bleday provide some pop and could threaten Allen if he leaves pitches up.

Cleveland has the edge in bullpen depth and late-game execution. Oakland will need to capitalize early if they want to avoid Cleveland’s shutdown arms in the final frames. Look for a close game, but a strong bullpen and small-ball execution might be the difference for the home side.

Cleveland has the opportunity to pull off a gritty win behind Allen and the bullpen. The guardians ability to limit late threats and manufacture a key insurance run makes the difference. The Guardians’ depth and discipline will decide this one. Take the Guardians. Final Score Prediction, Cleveland Guardians win 3-2.