Guardians vs Pirates Picks and Prediction – 4/19/2025

The Cleveland Guardians play the second game of a three-game series on the road Saturday versus the Pittsburgh Pirates. Cleveland is 9-9 following its 6-2 loss on Thursday to the Baltimore Orioles. Cleveland opened its three-game series versus Baltimore with a victory but lost each of the next two. The Guardians are second in the American League Central, 1 ½ games behind the first-place Detroit Tigers. Keep up to date with all the MLB action with our MLB predictions.

Steven Kwan is batting .310 to lead Cleveland and has team highs in RBI with 11, hits with 22, and on-base percentage at .364. Jose Ramirez is the leader in home runs with four. Cleveland is batting .228 with a .380 slugging percentage. On Saturday, Cleveland will send Ben Lively to the mound. The right-hander is 0-2 with a 4.87 ERA, 16 Ks, and 7 BBs.

The Pittsburgh Pirates improved to 8-12 following a 1-0 victory over the Washington Nationals on Thursday. Oneil Cruz hit a leadoff home run, and Andrew Heaney threw 7.1 innings of shutout baseball to help lead Pittsburgh to the win. Pittsburgh has won two straight and three of the last four, but trails first place in the National League Central live 3 ½ games.

Isiah Kiner-Falefa is batting .270 with 17 hits to lead Pittsburgh. Oneil Cruz is the leader in home runs with four, RBI with 10, and on-base percentage at .352. Pittsburgh has 13 home runs in 20 games. Pittsburgh is batting .197 with a slugging percentage of .302. On Saturday, Pittsburgh will send Paul Skenes to the mound. The right-hander is 2-1 with a 2.96 ERA, 26 Ks, and 3 BBs.

While the UNDER is a solid choice in this matchup, the play here is the Pittsburgh Pirates. Cleveland has lost four of the last five on the road and faces one of baseball's best young pitchers. Cleveland starter Ben Lively was roughed up last time out, allowing four runs on seven hits across six innings. Pittsburgh starter Paul Skenes is coming off a strong outing in which the right-hander allowed one run on three hits across six innings. Final Score Prediction: Pittsburgh Pirates win 4-1.