Guardians vs Twins Picks and Prediction – 5/21/2025

The Cleveland Guardians complete a three-game series on the road Wednesday versus the Minnesota Twins. Cleveland is 25-21 following its 3-1 loss to the Cincinnati Reds on Sunday. The Guardians' opening game of this series, scheduled for Monday, was suspended due to rain and will be continued as part of a doubleheader on Tuesday. The Guardians have lost four straight and six of the last eight. Cleveland trails first place in the American League Central by 5 games. Keep up to date with all the MLB action with our expert MLB picks.

Steven Kwan is batting .311 to lead Cleveland and has team highs in hits with 56 and on-base percentage with .374. Kyle Manzardo is the leader in home runs with 10 and in RBI with 25. Cleveland is batting .233 with a .380 slugging percentage. On Wednesday, Cleveland will send Tanner Bibee to the mound. The right-hander is 3-4 with a 4.06 ERA, 35 Ks, and 17 BBs.

The Minnesota Twins dropped to 26-21 following Sunday’s 5-2 loss to the Milwaukee Brewers, which snapped the Twins’ 13-game winning streak. Minnesota is third in ERA at 3.20 and in WHIP at 1.14. Minnesota is tied for second in the American League Central with Kansas City, 4 ½ games behind the first-place Detroit Tigers. 

Byron Buxton is batting .261 with 10 home runs and 27 RBI to lead Minnesota in the three categories, but is out with a concussion. Ty France is the leader in hits with 42, and Trevor Larnach is the leader in on-base percentage with .325. Minnesota is batting .242 with a .386 slugging percentage. On Wednesday, the Minnesota Twins will send Joe Ryan to the mound. The right-hander is 4-2 with a 2.42 ERA, 63 Ks, and 6 BBs.

Cleveland has lost four of its last five, while Minnesota has won 13 of its last 14, and the Twins have won each of the last nine played at home. Cleveland starter Tanner Bibee is coming off a poor outing in which the right-hander allowed four runs on 10 hits across six innings. Minnesota starter Joe Ryan has had four consecutive strong outings, allowing two runs on 12 hits across 25 innings. Final Score Prediction: Minnesota Twins win 5-2.