Guardians vs Twins Picks and Prediction – 5/20/2025

The Cleveland Guardians play the second game of a three-game series on the road Tuesday versus the Minnesota Twins. Cleveland is 25-21 following its 3-1 loss to the Cincinnati Reds on Sunday. Cleveland was swept by Cincinnati in its three-game series. The Guardians have lost four straight and six of the last eight. Cleveland trails first place in the American League Central by 5 ½ games. Keep up to date with all the MLB action with our MLB picks.

Steven Kwan is batting .311 to lead Cleveland and has team highs in hits with 56 and on-base percentage with .374. Kyle Manzardo is the leader in home runs with 10 and in RBI with 25. Cleveland is batting .233 with a .380 slugging percentage. On Tuesday, Cleveland will send Gavin Williams to the mound. The right-hander is 3-2 with a 4.29 ERA, 51 Ks, and 24 BBs.

The Minnesota Twins dropped to 26-21 following Sunday’s 5-2 loss to the Milwaukee Brewers, which snapped the Twins’ 13-game winning streak. Minnesota is 3rd in team ERA and WHIP at 3.20 and 1.14, respectively.

Minnesota is second in the American League Central, five games behind the first-place Detroit Tigers. 

Byron Buxton is batting .261 with 10 home runs and 27 RBI to lead Minnesota in the three categories, but is out with a concussion. Ty France is the leader in hits with 42, and Trevor Larnach is the leader in on-base percentage with .325. Minnesota is batting .242 with a .386 slugging percentage. On Tuesday, Minnesota will send Chris Paddock to the mound. The right-hander is 2-3 with a 4.05 ERA, 33 Ks, and 17 BBs.

Minnesota will win at home on Tuesday when hosting Cleveland, but the play here is UNDER. The UNDER has cashed in six of the Guardians’ last seven and 13 of the Twins’ last 18. Cleveland starter Gavin Williams has had three consecutive strong outings, allowing four runs across 14 innings. Minnesota starter Chris Paddock has had two consecutive strong outings, allowing one run on six hits across 14.1 innings. Final Score Prediction: Minnesota Twins win but our best play is UNDER 4-2.