Guardians vs Angels Picks and Prediction – 4/6/2025

By: Jeremy O’Quinn |

Last Updated: 04/04/2025 at 10:23 PM ET

Cleveland Guardians at Los Angeles Angels 04/05/25 - MLB Picks & Predictions
Game Start: 4/6/2025, 1:38 AM UTC
Latest Odds: CLE -145 ; O/U 7.5

Guardians vs Angels Prediction

The Cleveland Guardians are heading to Angel Stadium on Saturday, where they will take on the Los Angeles Angels. Get the rest of our free MLB Picks here! The Angels now sit second in the AL West, coming into Friday night’s game with a 4-2 record. The Angels snapped their four game win streak on Wednesday, when they suffered a 12-5 loss against St. Louis. Jack Kochanowicz will be the Angels’ starting pitcher on Saturday, this will be his first appearance on the mound this season. Los Angeles is putting up 6.5 hits and 4.0 runs per game, while giving up 5.5 runs a game.

The Cleveland Guardians have put together a record of 2-4 which places them second in the AL Central. The Guardians come into this series losing three straight games, as they closed out their series against the Padres with a 5-2 loss on Wednesday. Gavin Williams is set to be Cleveland’s starting pitcher on Saturday, he’s posted a 3.60 ERA through just 5 innings of play this season. The Guardians are putting up 3.3 runs per game, while giving up 4.8 a game.

Guardians vs Angels Pick Analysis

The Angels hope to bounce back after a tough loss against St. Louis, while the Guardians are desperate to bring their losing skid to an end. Expect the Guardians to come out on top in this one and cover the -1.5 spread. Final score prediction, Cleveland wins 5-3.

Our Free MLB Pick for Los Angeles Angels vs Cleveland Guardians

Cleveland Guardians -1.5