Guardians vs Astros Picks and Prediction – 7/10/2025

The Cleveland Guardians (41-48) head into Daikin Park to face the Houston Astros (55-36) this Wednesday at 6:10 PM ET. Cleveland took the opener of the series 7-5 on Monday, snapping a four-game losing skid. Slade Cecconi (3-4, 3.56 ERA) is set to duel against Houston’s Brandon Walter (1-1, 4.15 ERA) in an intriguing pitching matchup. Elevate your MLB game with our top-notch MLB picks.

The Cleveland Guardians snapped a four-game losing streak by defeating the Astros 7-5 in the series opener. The offense finally clicked for Cleveland after a troubling stretch, scoring more runs (7) than in the previous four games combined (4). The Guardians hope this marks an offensive turnaround, given recent offensive woes with just 312 runs scored this year, ranking among MLB's lowest totals.

On the mound, Cleveland leans on solid pitching, posting a team ERA of 3.96. Cecconi (1.31 WHIP, 47 Ks in 48 innings) faces a tough task against Houston’s powerful lineup. Cleveland's key bat is José Ramírez, batting .298 with 15 HR and 42 RBI. Injuries, however, plague Cleveland as Gabriel Arias and Lane Thomas remain sidelined, thinning an already inconsistent offense.

The Houston Astros look to bounce back from Monday's loss after previously winning three straight, including a dominant 18-1 performance over the Dodgers last weekend. The Astros' powerful offense, tallying 396 runs this season, struggled somewhat in the recent defeat but remains formidable. Isaac Paredes, leading the team with 19 HR and 49 RBI, will be key in restoring offensive dominance.

Houston boasts superior numbers on the mound with a team ERA of 3.48 and a stellar WHIP of 1.16. Walter has been efficient on the mound, striking out 33 in 34.2 innings with only 2 walks allowed. Injuries could pose challenges for Houston; Jeremy Pena (.322 AVG) and Chas McCormick are both significant absences, possibly affecting run production.

The Houston Astros, despite Monday’s slip-up, possess clear advantages. Astros' pitching has allowed fewer runs (3.48 ERA vs Cleveland’s 3.96 ERA) and fewer base runners (1.16 WHIP vs Guardians' 1.36). The offense is vastly superior (396 runs vs 312), and the Guardians’ injury concerns further tip the balance. Expect Houston to bounce back convincingly. Final Score Prediction: Astros win 6-3.