Guardians vs Tigers Picks and Prediction – 5/25/2025

By: David Anicetti |

Last Updated: 05/24/2025 at 9:42 PM ET

Cleveland Guardians at Detroit Tigers 05/25/25 - MLB Picks & Predictions
Game Start: 5/25/2025, 3:35 PM UTC
Latest Odds: DET -220 ; O/U 7.5

Guardians vs Tigers Prediction

The Cleveland Guardians complete a four-game series on the road Sunday versus the Detroit Tigers. Cleveland improved to 28-22 following Friday´s 3-1 victory over the Tigers. The Guardians have won three straight. Cleveland is tied for second with Minnesota in the American League Central, four games behind the first-place Tigers. Keep up to date with all the MLB action with our MLB picks.

Steven Kwan is batting .322 to lead Cleveland and has team highs in hits with 64 and on-base percentage at .378. Kyle Manzardo is the leader in home runs with 10, and Carlos Santana is the leader in RBI with 27. Cleveland is batting .233 with a .381 slugging percentage. On Sunday, Cleveland will send Logan Allen to the mound. The left-hander is 2-2 with a 3.86 ERA, 34 Ks, and 21 BBs.

The Detroit Tigers dropped to 33-19 following Friday’s two-run loss to the Guardians. The Tigers have lost two straight and three of the last five. Detroit is 4th in runs scored and 7th in team batting average, while sixth in team ERA. The Tigers lead the American League Central by four games over both the Minnesota Twins and the Guardians. 

Riley Greene is batting .280 with 54 hits to lead Detroit in both categories. Spencer Torkelson is the leader in home runs with 13 and RBI with 40, while Zach McKinstry is the leader in on-base percentage at .357. Detroit is batting .255 with a .415 slugging percentage. On Sunday, Detroit will send Tarik Skubal to the mound. The left-hander is 4-2 with a 2.87 ERA, 79 Ks, and 7 BBs.

Guardians vs Tigers Pick Analysis

Cleveland has won four of the last five head-to-head versus Detroit, and the Guardians have won five of the last six played on the road versus the Tigers. Cleveland starter Logan Allen has had two consecutive strong outings, allowing two runs on seven hits across 9 innings. Detroit starter Tarik Skubal has struggled in each of the last two outings, allowing eight runs on 12 hits across 12 innings. Final Score Prediction: Cleveland Guardians win 5-2.

Our Free MLB Pick for Detroit Tigers vs Cleveland Guardians

Cleveland Guardians +200