Guardians vs Tigers Picks and Prediction – 5/24/2025

The Cleveland Guardians (27–22) continue their four-game series against the AL Central-leading Detroit Tigers (33–18) on Saturday, May 24, 2025, at Comerica Park. First pitch is scheduled for 7:15 PM ET, with national coverage on FOX. The Guardians aim to build on their recent momentum, while the Tigers look to rebound and maintain their division lead. Get in on the action with our free MLB picks.

The Guardians have satrted to turn momentum around with wins in their last two games. Their offense has been sparked by outfielder Steven Kwan, who boasts a .314 batting average, and José Ramírez, power hittin for 9 home runs and 24 RBIs. On the mound, right-hander Luis Ortiz (2–5, 4.66 ERA) is slated to start. Ortiz has struggled with consistency this season, and the Guardians will look for a solid performance to keep pace with the Tigers' potent lineup.

The Tigers have been one of the most consistent teams in the league, holding a 33–18 record and leading the AL Central. Their offense is led by Riley Greene, who is hitting .281 with 12 home runs, and Spencer Torkelson, who has driven in 39 RBIs. Right-hander Casey Mize (6–1, 2.53 ERA) will take the mound for Detroit. Mize has been dominant, providing stability at the top of the rotation.

The Tigers' combination of strong pitching and a balanced offense gives them the edge in this matchup. The discrepancy in starting pitching is just too great to ignore in this game. We will back the Tigers to stifle the Cleveland bats and take a win at home, by a score of 6-3.