Guardians vs Tigers Picks and Prediction – 5/23/2025

The Cleveland Guardians play the second game of a four-game series on the road Friday versus the Detroit Tigers. Cleveland improved to 26-22 following Wednesday’s 5-1 victory over the Minnesota Twins, snapping a five-game losing streak by the Guardians. Cleveland is fourth in the American League Central, six games behind the first-place Detroit Tigers. Keep up to date with all the MLB action with our MLB picks.

Steven Kwan is batting .317 to lead Cleveland and has team highs in hits with 60 and on-base percentage at .377. Kyle Manzardo is the leader in home runs with 10 and in RBI with 26. Cleveland is batting .234 with a .382 slugging percentage. On Friday, the Cleveland Guardians will send Slade Cecconi to the mound. The right-hander is 0-1 with a 5.40 ERA, 8 Ks, and 0 BBs.

The Detroit Tigers improved to 33-17 following Wednesday’s 5-1 victory over the St. Louis Cardinals. Spencer Torkelson had two hits and one RBI to help lead the Tigers to the win. Detroit won two out of three over St. Louis. The Tigers lead the American League Central by 5 ½ games over both the Minnesota Twins and the Kansas City Royals. 

Riley Greene is batting .287 with 12 home runs and 54 hits to lead Detroit in each category. Spencer Torkelson is the leader in RBI with 39, and Zach McKinstry is the leader in on-base percentage at .365. Detroit is batting .259 with a .421 slugging percentage. On Friday, Detroit will send Jackson Jobe to the mound. The right-hander is 4-0 with a 4.12 ERA, 32 Ks, and 22 BBs.

Detroit will win at home on Friday, but the play here is OVER. The OVER has cashed in 13 of Detroit's last 20, in four of Detroit's last six at home, and five of the last seven Detroit has played at home versus the Guardians. Cleveland starter Slade Cecconi was hit hard in his only appearance thus far, allowing three runs on five hits across five innings. Detroit starter Jackson Jobe has had two straight strong outings, allowing three runs on nine hits across 11.2 innings. Final Score Prediction: Detroit Tigers win but our best play is OVER 9-2.