Guardians vs Reds Picks and Prediction – 5/16/2025

The Great American Ball Park will play host to a Friday night MLB interleague clash between the Cleveland Guardians and the Cincinnati Reds. Be ready for the baseball season with all of our MLB predictions. The Guardians (25-18) are a game above .500 on the road and trail AL Central Division leading Detroit by 3.5 games. On Wednesday, All-Star Jose Ramirez’s three-run blast was not enough during a 9-5 home loss versus Milwaukee. 

Twenty-six year old righty Tanner Bibee (3-3 3.80 ERA) will take the mound for the Guardians in this matchup. In his last start, Bibee (7 IP) gave up five hits and one run during a 7-1 home loss versus Philadelphia. 

The Cincinnati Reds are two games below .500 at home and are 4.5 games off the pace in the NL Central Division race. On Thursday, OF Will Benson went 2-for-3 with a home run and three RBIs to lead Cincinnati to a 7-1 home victory versus the Chicago White Sox. Elly De La Cruz and Matt McLain also went deep for the Reds, who improved to 21-24 on the year. 

Cincinnati skipper Terry Francona will give the nod to right-hander Brady Singer (4-2 4.97 ERA) on Friday. Last time out, Singer surrendered seven runs and recorded just seven outs during a wild 13-9 road victory against Houston. 

Cincinnati SP Hunter Greene is currently on the 15-day injured list with a Grade 1 right groin strain Through 43 games, Cleveland ranks 20th in OPS and 18th in runs scored. For the season, Cincinnati ranks 16th in OPS and 11th in runs scored. Take the Guardians to win on the road. Final Score Prediction, Cleveland Guardians win 6-3.