Cleveland Guardians at Chicago White Sox 7/22/22 - MLB Picks & Predictions

Last Updated: 07/21/2022 at 10:20 PM ET

Cleveland Guardians at Chicago White Sox 7/22/22 - MLB Picks & Predictions

On Friday, the Cleveland Guardians open a three-game series on the road against the Chicago White Sox. Cleveland is 46-44 following its 10-0 victory over the Detroit Tigers last Saturday. Cleveland's game on Sunday versus the Tigers was postponed due to rain. The Guardians have won three straight and are second in the American League Central, two games behind the first-place Minnesota Twins.Cleveland and Minnesota not your team? Check out all of our MLB game day picks!

Second baseman Andres Gimenez is batting .296 to lead Cleveland and shortstop Amed Rosario is the leader in hits with 99. Third baseman Jose Ramirez has 19 home runs, 75 RBIs and an on-base percentage of .368 to lead Cleveland in each category. On Friday, the Cleveland Guardians will send Cal Quantrill to the mound. The right-hander is 6-5 with a 3.75 ERA, 63 Ks and 30 BBs.

Chicago is 46-46 following its 11-0 victory over the Minnesota Twins last Sunday. Chicago defeated Minnesota in three out of four games and their series prior to the All-Star Game break. The White Sox have won five out of the last six and are third in the American League Central, three games behind the first-place Twins.

Shortstop Tim Anderson is batting .310 to lead Chicago, while center fielder Luis Robert is the leader in home runs with 12 and RBIs with 54. First baseman Jose Abreu is the leader in on-base percentage at .387 and hits with 105. On Friday, the Chicago White Sox will send Lucas Giolito to the mound. The right-hander is 6-5 with a 4.69 ERA, 102 Ks and 32 BBs.

Cleveland has won five of its last seven overall and the Guardians have won six of the last nine head-to-head with Chicago. Chicago has lost eight of its last 12 played at home. Cleveland starting pitcher Cal Quantrill is coming off a strong outing in which the right-hander allowed no runs on four hits across six Innings resulting in a 10-0 victory over Detroit last Saturday. Final Score Prediction, Cleveland Guardians win 6-4.

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