Guardians vs White Sox Picks and Prediction – 7/13/2025

The Cleveland Guardians complete a four-game series on the road Sunday versus the Chicago White Sox. Cleveland is 44-49 following a 5-4 loss to Chicago on Friday in the second game of a doubleheader. Cleveland won the first game of the twinbill 4-2. The Guardians are fourth in the American League Central, 14 games behind the first-place Detroit Tigers. Keep up to date with all the MLB action with our expert MLB picks.

Jose Ramirez is batting .297 with 18 home runs, 47 RBI, and an on-base percentage of .364 to lead Cleveland in each of the four categories. Steven Kwan leads in hits with 102. Cleveland is batting .223 with a .367 slugging percentage. On Sunday, the Cleveland Guardians will send Joey Cantillo to the mound. The left-hander is 1-0 with a 3.79 ERA, 48 Ks, and 20 BBs.

The Chicago White Sox improved to 32-63 following Friday’s one-run victory over Cleveland to split a doubleheader. Mike Tauchman had an infield single in the 11th inning to knock in the winning run and give Chicago the walk-off victory. Chicago is last in the American League Central, trailing the first-place Tigers by 27 games.

Lenya Sosa is batting .272 to lead Chicago and has a team high of 76 hits. Andrew Benintendi leads in home runs with 10, while Miguel Vargas leads in RBI with 35 and on-base percentage at .299. Chicago is batting .220 with a .344 slugging percentage. On Sunday, Chicago will send Aaron Civale to the mound. The right-hander is 1-6 with a 5.17 ERA, 33 Ks, and 20 BBs.

Chicago will win at home on Sunday when hosting Cleveland, but the play here is OVER. The OVER has cashed in four of Cleveland's last six and seven of Chicago's last 10 versus an opponent from the American League Central. Cleveland starter Joey Cantillo will be making just his third start, and in two previous starts, he gave up three runs on seven hits across 7.1 innings. Chicago starter Aaron Civale was hit hard last time out, allowing five runs on seven hits across 4.0 innings. Final Score Prediction: Chicago White Sox win but our best play is OVER 7-5.