Guardians vs White Sox Picks and Prediction – 7/12/2025

The Cleveland Guardians play the second game of a four-game series on the road Friday versus the Chicago White Sox. Cleveland is 43-48 following Wednesday’s 4-2 victory over the Houston Astros. Cleveland swept Houston in its three-game series, following a 10-game losing streak. Cleveland is 4th in the American League Central, 14 ½ games behind first-place Detroit. Keep up to date with all the MLB action with our expert MLB picks.

Jose Ramirez is batting .301 with 17 home runs, 45 RBI, and an on-base percentage of .366 to lead Cleveland in each of the four categories. Steven Kwan leads in hits with 101. Cleveland is batting .224 with a .366 slugging percentage. On Friday, Cleveland will send Gavin Williams to the mound. The right-hander is 5-4 with a 3.61 ERA, 90 Ks, and 52 BBs.

The Chicago White Sox improved to 31-62 following Wednesday’s 2-1 victory over the Toronto Blue Jays. Chicago starter Adrian Houser allowed one run on seven hits across seven innings to help lead the White Sox to the victory. Chicago snapped a three-game losing streak with Wednesday’s win. The White Sox are last in the American League Central, 27 ½ games behind first-place Detroit.

Lenya Sosa is batting .272 to lead Chicago and has a team high of 74 hits. Andrew Benintendi leads in home runs with 10 and RBI with 34, while Miguel Vargas leads in on-base percentage at .301. Chicago is batting .222 with a .345 slugging percentage. On Friday, Chicago will send Shane Smith to the mound. The right-hander is 3-7 with a 4.20 ERA, 76 Ks, and 37 BBs.

Cleveland has dominated Chicago, winning each of the last seven head-to-head games versus the White Sox. Cleveland starter Gavin Williams is coming off a strong outing in which the right-hander allowed no runs on one hit across six innings versus the Detroit Tigers. Chicago starter Shane Smith has been hit hard in four straight outings, allowing 21 runs across 15.1 innings. Final Score Prediction: Cleveland Guardians win 6-3.