Guardians vs Orioles Picks and Prediction – 4/15/2025

TBS will feature a Tuesday night MLB matchup between the Cleveland Guardians and the Baltimore Orioles from Camden Yards. Be ready for the baseball season with all of our MLB predictions. The Guardians (8-7) have dropped six of their first nine road games and trail Detroit by one game for first place in the AL Central Division. On Sunday, Cleveland SP Ben Lively (0-2) gave up four runs in six innings during a 4-2 home loss versus Kansas City.

Twenty-six year old southpaw Logan Allen (0-1 3.60 ERA) will make his third start of the year for the Guardians. Control has been an issue for Allen, who has issued seven walks and given up 11 hits through ten innings. 

The Baltimore Orioles have lost seven of their previous ten games and are stuck in the AL East Division basement. On Sunday, Baltimore batters went 0-for-13 with runners in scoring position and left eight men on base during a disappointing 7-6 home loss versus Toronto. SS Gunnar Henderson went 3-for-5 and scored twice for the Orioles, who fell to 2-3 at home. 

Forty-one year old righty Charlie Morton (0-3 8.78 ERA) has gotten off to a rough start with the Orioles. Last time out, Morton (5 IP) walked five batters and surrendered four runs during a 4-3 road loss against Arizona. 

Baltimore starting pitchers Grayson Rodriguez (elbow) and Zach Eflin (lat) are currently on the 15-day injured list. Through 16 games, Cleveland ranks 19th in OPS and 23rd in runs scored. For the regular season, Baltimore ranks 16th in OPS and 13th in runs scored. Take the Guardians to win on the road. Final Score Prediction, Cleveland Guardians win 5-3.