Guardians vs Orioles Picks and Prediction – 4/16/2025

The Cleveland Guardians play the second game of a three-game series on the road Wednesday versus the Baltimore Orioles. Cleveland is 8-7 following its 4-2 loss to the Kansas City Royals on Sunday in the final game of a three-game series in which Cleveland won the first two. The Guardians are second in the American League Central, 1 ½ games behind the first-place Detroit Tigers. Keep up to date with all the MLB action with our MLB picks.

Stephen Kwan is batting .322 with 19 hits and an on-base percentage of .375 to lead Cleveland in the three statistics. Jose Ramirez is the leader in home runs with four, and Kyle Manzardo is the leader in RBI with 11. Cleveland has a batting average of .222 and a slugging percentage of .373. On Wednesday, Cleveland will send Gavin Williams to the mound. The right-hander is 1-0 with a 3.46 ERA, 14 Ks, and 6 BBs.

The Baltimore Orioles dropped to 6-9 following a 7-6 loss to the Toronto Blue Jays on Sunday. Baltimore won the second game of the series on Saturday, 5-4, after the first game on Friday had been rained out. Baltimore is last in the American League East, 2 ½ games behind the first-place New York Yankees. The Orioles have lost three of the last four.

Tyler O'Neill is batting .289 to lead Baltimore, and Adley Rutschman is the leader in hits with 14. Cedric Mullins is the leader in home runs with three, RBI with 16, and on-base percentage at .414. Baltimore is batting .235 with a .383 slugging percentage. On Wednesday, the Orioles will send Dean Kremer to the mound. The right-hander is 1-2 with an 8.16 ERA, 11 Ks, and 3 BBs.

Cleveland has won five of its last six while Baltimore has lost seven of its last 10, and the Orioles are 2-5 in the last seven head-to-head versus the Guardians. Cleveland starter Gavin Williams has allowed five runs across 13 innings in three starts. Baltimore starter Dean Kremer is coming off a poor outing in which the right-hander allowed six runs on eight hits across 4.2 innings. Final Score Prediction: Cleveland Guardians win 5-3.