Reds vs Cardinals Picks and Prediction – 6/22/2025

The Cincinnati Reds complete a three-game series on the road Sunday versus the St Louis Cardinals. Cincinnati is 39-37 following its 6-1 loss on Friday to St Louis in the opening game of the series. Cincinnati has lost each of its last two and has given up 18 runs over the two losses, which follows a four-game winning streak. Cincinnati trails first place in the National League Central by 6 ½ games. Keep up to date with all the MLB action with our MLB predictions.

TJ Friedl is batting .290 with 80 hits and an on-base percentage of .379 to lead Cincinnati in the three categories. Elly De La Cruz leads Cincinnati in home runs with 16 and in RBI with 50. The Reds are batting .247 with a .401 slugging percentage. On Sunday, Cincinnati will send Andrew Abbott to the mound. The left-hander is 6-1 with a 1.84 ERA, 69 Ks, and 20 BBs.

With Friday’s five-run victory, the St Louis Cardinals improved to 41-35. Andre Pallante gave up just two hits across six scoreless innings for the Cardinals. St Louis scored five runs in the eighth inning to beat the Reds. The Cardinals have won four straight and five of the last six. St Louis is tied for second with Milwaukee in the NL Central, 4 ½ games behind first-place Chicago.

Brendan Donovan is batting .313 with 83 hits and an on-base percentage of .382 to lead St Louis in the three categories. Willson Contreras leads the Cardinals in home runs with 10 and RBI with 50. St Louis is batting .257 with a .395 slugging percentage. On Sunday, St Louis will send Miles Mikolas to the mound. The right-hander is 4-4 with a 4.35 ERA, 45 Ks, and 18 BBs.

Cincinnati has won nine of its last 13, and the Reds have won four of the last six versus an opponent from the National League. St Louis has lost four of its last five at home. Cincinnati starter Andrew Abbott has had two consecutive strong outings, allowing one run on 11 hits across 14.2 innings, which includes a complete-game 1-0 victory over Cleveland. St Louis starter Miles Mikolas has allowed 15 runs across the last 21 innings. Final Score Prediction: Cincinnati Reds win 6-2.