Reds vs Pirates Picks and Prediction – 5/20/2025

By: Eddie Kline |

Last Updated: 05/19/2025 at 10:33 PM ET

Cincinnati Reds at Pittsburgh Pirates 05/20/25 - MLB Picks & Predictions
Game Start: 5/20/2025, 10:40 PM UTC
Latest Odds: CIN -125 ; O/U 8

Reds vs Pirates Prediction

Scenic PNC Park will play host to a Tuesday night MLB clash between the Cincinnati Reds and the Pittsburgh Pirates. Be ready for the baseball season with all of our MLB predictions.The Reds (25-24) are riding a five-game winning streak and are 3.5 games off the pace in the NL Central Division race. Last night, SS Elly De La Cruz doubled twice and drove in a pair of runs to lead Cincinnati to a 7-1 road victory against Pittsburgh. 

Thirty-four year old righty Nick Martinez (2-4 3.66 ERA) will head to the hill for the Reds in this matchup. Last time out, Martinez fired seven shutout frames and allowed just a pair of hits during a 7-1 home victory versus the Chicago White Sox. 

The Pittsburgh Pirates are looking to snap a four-game losing streak and are trapped in the NL Central Division cellar. During Monday’s home loss, Ke’Bryan Hayes and Andrew McCutchen went a combined 0-for-8 with four strikeouts. SP Mitch Keller (1-6) gave up one earned run in six innings and took the loss for the Pirates (15-33), who fell to 9-14 at home. 

The Pirates will counter with twenty-eight year old southpaw Bailey Falter (2-3 4.02 ERA) on Tuesday. Pittsburgh has won Bailey’s last two starts and he has held the opposition scoreless over his last nine plus frames. 

Reds vs Pirates Pick Analysis

Cincinnati SP Hunter Green (groin) threw a bullpen session on Saturday and could rejoin the rotation this weekend. Through 49 games, Cincinnati ranks 13th in OPS and 9th in runs scored. For the season, Pittsburgh ranks 30th in OPS and 30th in runs scored. Take the Reds to win on the road. Final Score Prediction, Cincinnati Reds win 5-3.

Our Free MLB Pick for Pittsburgh Pirates vs Cincinnati Reds

Cincinnati Reds -125