Reds vs Marlins Picks and Prediction – 4/22/2025

By: Eddie Kline |

Last Updated: 04/21/2025 at 10:52 PM ET

Cincinnati Reds at Miami Marlins 04/22/25 - MLB Picks & Predictions
Game Start: 4/22/2025, 10:40 PM UTC
Latest Odds: CIN -125 ; O/U 8.5

Reds vs Marlins Prediction

In Tuesday night MLB action, the Cincinnati Reds and the Miami Marlins will continue their series from loanDepot Park. Be ready for the baseball season with all of our MLB predictions. The Reds (11-12) are a game below .500 on the road and are 2.5 games off the pace in the NL Central Division race. Last night, Cincinnati batters went 1-for-10 with runners in scoring position and left six men on base during a 6-3 road loss. 

Thirty-four year old southpaw Nick Martinez (0-3 6.00 ERA) will head to the hill for the Reds in this contest. Cincinnati is winless in Martinez’s previous four starts and he has struck out 19 batters through 21 innings.

The Miami Marlins have split their first 14 home games and are sitting in third place in the NL East Division standings. During Monday’s home victory, Kyle Stowers delivered a pinch-hit three-run blast to give Miami a 6-0 advantage. SP Max Meyer (2-2) fanned 14 batters across six shutout frames to earn the win for the Marlins, who improved to 10-12 overall.  

The Marlins will counter with hard-throwing righty Edward Cabrera (0-1 6.52 ERA) on Tuesday. In his last start, Cabrera (4 IP) walked three batters and gave up five runs during a 6-4 home loss versus Arizona. 

Reds vs Marlins Pick Analysis

Miami OF Griffin Conine has been placed on the 60-day injured list with a dislocated left shoulder. Through 23 games, Cincinnati ranks 9th in OPS and 4th in runs scored. For the regular season, Miami ranks 14th in OPS and 16th in runs scored. Take the over. Final Score Prediction, Cincinnati Reds win 6-5.

Our Free MLB Pick for Miami Marlins vs Cincinnati Reds

OVER 8.5