Reds vs Astros Picks and Prediction – 5/10/2025

The Cincinnati Reds open a three-game series on the road Friday versus the Houston Astros. Cincinnati is 19-19 following its 4-3 win over the Atlanta Braves on Wednesday, snapping a four-game losing streak. The Reds complete a four-game series with Atlanta on Thursday. Cincinnati is tied for second with Milwaukee and St Louis in the National League Central, three games behind the first-place Milwaukee Brewers. Keep up to date with all the MLB action with our expert MLB picks.

Gavin Lux is batting .302 with an on-base percentage of .396 to lead Cincinnati in both categories. Austin Hays is the leader in home runs with five, and Elly De La Cruz is the leader in RBI with 25. TJ Friedl is the leader in hits with 39. On Friday, the Cincinnati Reds will send Nick Martinez to the mound. The right-hander is 1-3 with a 4.19 ERA, 32 Ks, and 11 BBs.

The Houston Astros improved to 18-18 following Wednesday’s 9-1 victory over the Milwaukee Brewers. Houston snapped a three-game losing streak with the win. Framber Valdez pitched seven solid innings. Houston is third in the American League West, four games behind the first-place Seattle Mariners. 

Jake Meyers is batting .297 to lead Houston. Jeremy Pena is the leader in home runs with five and hits with 38. Yordan Alvarez is the leader in the RBI with 18, and Isaac Paredes is the leader in on-base percentage at .368. Houston is batting .241 with a .366 slugging percentage. On Friday, Houston will send Hunter Brown to the mound. The right-hander is 5-1 with a 1.67 ERA, 49 Ks, and 10 BBs.

Houston has lost four of the last six, and the Astros are 4-7 in the last 11 versus an opponent from the last 11. Cincinnati starter Nick Martinez has had three straight strong outings, allowing four runs on 14 hits across 17.2 innings. Hunter Brown was hit hard last time out, allowing three runs across six innings. Final Score Prediction: Cincinnati Reds win 6-3.