Reds vs Astros Picks and Prediction – 5/11/2025

The Cincinnati Reds complete a three-game series on the road Sunday versus the Houston Astros. Cincinnati is 19-21 following its 3-0 loss to Houston on Friday in the opening game of the series. The Reds have lost six of the last seven. Cincinnati is fourth in the National League Central, 3 ½ games behind the first-place Milwaukee Brewers. Keep up to date with all the MLB action with our expert MLB picks.

Gavin Lux is batting .290 with an on-base percentage of .385 to lead Cincinnati in both categories. Austin Hays is the leader in home runs with five, and Elly De La Cruz is the leader in RBI with 25. TJ Friedl is the leader in hits with 40. On Sunday, the Cincinnati Reds will send Chase Petty to the mound. The right-hander is 0-1 with a 34.71 ERA, 3 Ks, and 2 BBs.

The Houston Astros improved to 19-18 following Friday’s three-run shutout victory over the Reds. Hunter Brown had nine strikeouts on the mound for the Astros in the win. Brown allowed just two hits into the sixth inning for another strong effort on the mound. Houston is tied for second in the American League West with the Athletics, three games behind the first-place Seattle Mariners. 

Jake Meyers is batting .298 to lead Houston. Jeremy Pena is the leader in home runs with five and hits with 39. Yordan Alvarez is the leader in the RBI with 18, and Isaac Paredes is the leader in on-base percentage at .365. Houston is batting .244 with a .369 slugging percentage. On Sunday, Houston will send Ronel Blanco to the mound. The right-hander is 2-3 with a 4.98 ERA, 32 Ks, and 16 BBs.

Houston will pick up a victory at home on Sunday when hosting Cincinnati, but the play here is OVER. The OVER has cashed in eight of Houston's last 11. Cincinnati starter Chase Petty has an astronomical 34.71 ERA. Petty has made just one appearance this season, allowing nine runs across 2.1 innings. Houston starter Ronel Blanco has been hit hard in two straight outings, allowing six runs on 10 hits across 11 innings. Final Score Prediction: Houston Astros win, but our best play is OVER 8-4.