Reds vs Astros Picks and Prediction – 5/10/2025

The Cincinnati Reds play the second game of a three-game series on the road Saturday versus the Houston Astros. Cincinnati is 19-20 following its 5-4 loss to the Atlanta Braves on Thursday. The Reds have lost five of the last six. Cincinnati is fourth in the National League Central, 3 ½ games behind the first-place Milwaukee Brewers. Keep up to date with all the MLB action with our expert MLB picks.

Gavin Lux is batting .298 with an on-base percentage of .388 to lead Cincinnati in both categories. Austin Hays is the leader in home runs with five, and Elly De La Cruz is the leader in RBI with 25. TJ Friedl is the leader in hits with 40. On Saturday, the Cincinnati Reds will send Brady Singer to the mound. The right-hander is 4-2 with a 3.66 ERA, 38 Ks, and 14 BBs.

The Houston Astros are 18-18 following Wednesday’s 9-1 victory over the Milwaukee Brewers. Houston was off on Thursday and has lost three of the last four. Houston is a strong 6th in team ERA, but the Astros are only 20th in runs scored and 19th in team batting average. Houston is third in the American League West, four games behind the first-place Seattle Mariners. 

Jake Meyers is batting .297 to lead Houston. Jeremy Pena is the leader in home runs with five and hits with 38. Yordan Alvarez is the leader in the RBI with 18, and Isaac Paredes is the leader in on-base percentage at .368. Houston is batting .241 with a .366 slugging percentage. On Saturday, Houston will send Lance McCullers Jr to the mound. The right-hander is 0-0 with a 0.00 ERA, 4 Ks, and 3 BBs.

Houston has won five of its last six played at home, and Cincinnati has lost five of its last six overall. Cincinnati starter Brady Singer struggled last time out, allowing four runs on seven hits across 6.0 innings. Houston's starter, Lance McCullers Jr, gave up no runs on three hits across 3.2 innings in his first appearance of the season last Sunday. Final Score Prediction: Houston Astros win 5-3.