Reds vs Guardians Picks and Prediction – 6/11/2025

In-state rivals will square off on Wednesday afternoon, when the Cincinnati Reds battle the Cleveland Guardians from Progressive Field. Be ready for the baseball season with all of our MLB predictions. The Reds (35-33) are riding a five-game winning streak and are six games off the pace in the NL Central Division race. Last night, SP Andrew Abbott tossed a complete game three-hitter to lead Cincinnati to a 1-0 road victory against Cleveland. 

Twenty-seven year old southpaw Nick Lodolo (4-4 3.21 ERA) will head to the hill for the Reds in this contest. Through 75 plus innings, Lodolo has fanned 64 batters and owns a sparkling 1.08 WHIP.

The Cleveland Guardians have dropped seven of their previous 11 games and are 8.5 games behind AL Central Division leading Detroit. During Tuesday’s home loss, Cleveland batters went 0-for-4 with runners in scoring position and left four men on base. SP Slade Cecconi (1-3) fanned eight batters across five frames and was the hard luck loser for the Guardians (34-32), who fell to 18-15 at home.  

Cleveland skipper Terry Francona will turn to right-hander Logan Allen (3-4 4.42 ERA) on Wednesday. In his last start, Allen (6 IP) was tagged for seven hits and four runs during a 4-2 home loss versus Houston. 

Cincinnati SP Hunter Greene is headed to Los Angeles for a second opinion on his back/groin injuries and hopes to return later this month. Through 68 games, Cincinnati ranks 11th in OPS and 7th in runs scored. For the season, Cleveland ranks 23rd in OPS and 24th in runs scored. Take the over. Final Score Prediction, Cleveland Guardians win 7-4.