Reds vs Guardians Picks and Prediction – 6/10/2025

In Tuesday night MLB interleague action, the Cincinnati Reds will square off against the Cleveland Guardians from Progressive Field. Be ready for the baseball season with all of our MLB predictions. The Reds (34-33) are riding a four-game winning streak and are seven games off the pace in the NL Central Division race. Last night, OF Jake Fraley homered and collected three of Cincinnati’s 16 hits during a 7-4 road victory against Cleveland. 

Twenty-six year old southpaw Andrew Abbott (5-1 2.18 ERA) has been quietly pitching well for the Reds. Through 53 plus innings, Abbott has allowed just six home runs and fanned 59 batters while posting a sparkling 1.06 WHIP.

The Cleveland Guardians are four games above .500 at home and are eight games back of AL Central Division leading Detroit. During Monday’s home loss, Cleveland C Bo Naylor went 2-for-3 with a solo shot and two runs scored. SP Luis Ortiz (3-7) gave up four runs across four plus frames and took the loss for the Guardians, who fell to 34-31 overall.

Cleveland manager Stephen Vogt will turn to right-hander Slade Cecconi (1-2 4.87 ERA) on Tuesday. In his last start, Cecconi (5 IP) gave up five hits and two runs during a 4-0 road loss against New York. 

Cincinnati OF Austin Hays (foot) could be cleared for running this week and hopes to return later this month. Through 67 games, Cincinnati ranks 12th in OPS and 8th in runs scored. For the season, Cleveland ranks 23rd in OPS and 24th in runs scored. Take the Reds to win on the road. Final Score Prediction, Cincinnati Reds win 5-3.