Reds vs Orioles Picks and Prediction – 4/20/2025

Beautiful Camden Yards will be the scene for a Sunday MLB interleague clash between the Cincinnati Reds and the Baltimore Orioles. Be ready for the baseball season with all of our MLB predictions. The Reds (10-10) have won seven of their last ten games and trail NL Central Division leading Chicago by 2.5 games. On Saturday, Cincinnati batters went 4-for-17 with runners in scoring position and left 13 men on base during a 9-5 road loss against Baltimore. 

Twenty-seven year old righty Carson Spiers (0-2 4.82 ERA) will take the mound for the Reds in this matchup. Last time out, Spiers (3.1 IP) gave up five hits and four runs during an 8-2 road loss against Milwaukee. 

The Baltimore Orioles are a game below .500 at home and must improve a pitching staff that ranks in the bottom third of the majors with a 4.45 ERA. During yesterday’s home victory, Ramon Laureano came off the bench to power the Baltimore offense with two long balls and three RBIs. SS Gunnar Henderson also went deep and scored twice for the Orioles, who improved to 9-11 overall. 

The Orioles will counter with forty-one year old righty Charlie Morton (0-4 8.84 ERA) in the series finale. Through 18 plus innings, Morton has surrendered four home runs while posting an alarming 1.91 WHIP.

Baltimore starting pitchers Grayson Rodriguez (elbow/shoulder) and Zach Eflin (lat) are currently on the 15-day injured list. Through 21 games, Cincinnati ranks 23rd in OPS and 12th in runs scored. For the regular season, Baltimore ranks 17th in OPS and 13th in runs scored. Take the over. Final Score Prediction, Baltimore Orioles win 7-5.