White Sox vs Blue Jays Picks and Prediction – 6/21/2025

The Chicago White Sox play the second game of a three-game series on the road Saturday versus the Toronto Blue Jays. Chicago is 23-52 after being swept in a doubleheader by St. Louis, losing the opener 5-4 and the second game 8-6. Chicago has lost eight straight and trails first place in the American League Central by 24 ½ games. Keep up to date with all the MLB action with our MLB picks.

Miguel Vargas is batting .242 with 10 home runs, 32 RBI, 64 hits, and an on-base percentage of .320 to lead Chicago in each of the five categories. Chicago is batting .222 with a .342 slugging percentage. On Saturday, the Chicago White Sox will send Aaron Civale to the mound. The right-hander is 1-3 with a 4.67 ERA, 23 Ks, and 11 BBs.

The Toronto Blue Jays dropped to 40-34 following Thursday’s 9-4 loss to the Arizona Diamondbacks. Toronto had its two-game winning streak snapped by the loss. The Blue Jays have lost four of the last six. Toronto is third in the American League East, three games behind the first-place New York Yankees.

Alejandro Kirk is batting .312 to lead Toronto, and George Springer is the leader in home runs with 10. Bo Bichette leads in RBI with 44 and hits with 85, while Vladimir Guerrero Jr is the leader in on-base percentage at .388. Toronto is batting .256 with a .400 slugging percentage. On Saturday, the Toronto Blue Jays will send Jose Berrios to the mound. The right-hander is 2-3 with a 3.81 ERA, 76 Ks, and 33 BBs.

The Toronto Blue Jays will win at home on Saturday when hosting the Chicago White Sox, but the play here is OVER. The OVER has cashed in four of Toronto's last five and 11 of Toronto's last 12 played at home. Chicago starter Aaron Civale has allowed nine runs across the last 25 innings in five starts for a 3.24 ERA. Toronto starter Jose Berrios gave up six runs on nine hits across 4.2 innings last time out. Final Score Prediction: Toronto Blue Jays win but our best play is OVER 8-3.