White Sox vs Rays Picks and Prediction – 7/21/2025

The Chicago White Sox open a three-game series on the road Monday versus the Tampa Bay Rays. Chicago is 34-65 following Saturday’s 10-4 victory over the Pittsburgh Pirates. Mike Tauchman hit a three-run double to put Chicago ahead for good in the sixth inning. Lenya Sosa had three RBI for the White Sox. Chicago trails first-place Detroit and the American League Central by 25 games. Keep up to date with all the MLB action with our expert MLB picks.

Lenya Sosa is batting .274 with 81 hits to lead Chicago in both categories. Andrew Benintendi leads Chicago in home runs with 11, while Luis Robert Jr leads in RBI with 38, and Miguel Vargas is the leader in on-base percentage at .300. On Monday, Chicago will send Sean Burke to the mound. The right-hander is 4-8 with a 4.36 ERA, 80 Ks, and 43 BBs.

The Tampa Bay Rays improved to 52-47 following Saturday’s 4-3 victory over the Baltimore Orioles. Chandler Simpson hit an RBI single to tie the score and then scored the go-ahead run on a throwing error by the Orioles. Tampa Bay has won two straight since snapping a four-game losing streak. The Rays trail first-place Toronto in the American League East by 5 ½ games.

Jonathan Aranda is batting .316 with an on-base percentage of .392 to lead Tampa Bay in both categories. Junior Caminero leads in home runs with 25 and RBI with 64, while Yandy Diaz leads in hits with 109. Tampa Bay is batting .258 with a .407 slugging percentage. On Monday, Tampa Bay will send Shane Baz to the mound. The right-hander is 8-5 with a 4.17 ERA, 107 Ks, and 40 BBs.

Tampa Bay will pick up a victory at home on Monday when hosting Chicago, but the play here is OVER. The OVER has cashed in four of the White Sox’s last five, and six of Tampa Bay's last eight played at home. Chicago starter Sean Burke has been hit hard in two consecutive outings, allowing eight runs on nine hits across 10 innings. Tampa Bay starter Shane Baz has struggled in two of the last three outings, allowing seven runs on 19 hits across 19.1 innings. Final Score Prediction: Tampa Bay Rays win but our best play is OVER 7-5.