White Sox vs Twins Picks and Prediction – 4/23/2025

The Chicago White Sox play the second game of a three-game series on the road Wednesday versus the Minnesota Twins. Chicago dropped to 5-17 following Monday’s 4-2 loss to the Boston Red Sox. Chicago lost three out of four in its four-game series with the Red Sox at Fenway Park. Chicago has lost seven of the last eight and trails first place in the American League Central by 8 ½ games. Keep up to date with all the MLB action with our MLB picks.

Lenyn Sosa is batting .270 with 20 hits and an on-base percentage of .299 to lead Chicago in the three categories. Andrew Benintendi is the leader in home runs with four, and Andrew Vaughn is the leader in RBI with 10. The Chicago White Sox have not announced their starting pitcher for Wednesday's second game of a three-game series versus the Minnesota Twins.

The Minnesota Twins dropped to 7-15 following Sunday’s 6-2 loss to the Atlanta Braves. Minnesota was swept in its three-game series by Atlanta. The Twins gave up 16 runs in the three games while scoring just 9. Minnesota was off on Monday, and the Twins are fourth in the American League Central, 6 ½ games behind the first-place Detroit Tigers.

Byron Buxton is batting .244 to lead Minnesota and has team highs in home runs with four and hits with 19. Harrison Bader is the leader in RBI with 12, and Ty France is the leader in on-base percentage at .314. On Wednesday, the Minnesota Twins will send David Festa to the mound. The right-hander is 0-0 with a 0.00 ERA, 10 Ks, and 2 BBs.

Chicago has lost seven of its last eight, and although Minnesota has also struggled, the Twins have won each of the last 10 played at home versus the Chicago White Sox. Minnesota will also have a starter on the mound who has performed well early this season. Minnesota starting David Festa has had two consecutive strong outings, allowing no earned runs on eight hits across nine innings. Final Score Prediction: Minnesota Twins win 6-2.