White Sox vs Twins Picks and Prediction – 4/22/2025

The Chicago White Sox open a three-game series on the road Tuesday versus the Minnesota Twins. Chicago improved to 5-16 following its 8-4 victory over the Boston Red Sox on Sunday. Miguel Vaughn hit a two-run home run for Chicago. Chicago snapped a six-game losing streak with its victory on Sunday but is last in the American League Central, 7 ½ games behind first-place. Keep up to date with all the MLB action with our MLB predictions.

Lenyn Sosa is batting .271 with 19 hits and an on-base percentage of .301 to lead Chicago in the three categories. Andrew Benintendi is the leader in home runs with three, and Andrew Vaughn is the leader in RBI with 10. Chicago is batting .198 with a .306 slugging percentage. On Tuesday, Chicago will send Davis Martin to the mound. The right-hander is 1-2 with a 4.84 ERA, 13 Ks, and 6 BBs.

The Minnesota Twins look to snap a three-game losing streak with a victory on Tuesday when opening their series on the road versus the White Sox. Minnesota is 7-15 and lost to the Atlanta Braves 6-2 on Sunday. Minnesota was swept in its three-game series with Atlanta. The Twins are fourth in the American League Central, six games behind the first-place Detroit Tigers. 

Byron Buxton is batting .244 with four home runs and 19 hits to lead Minnesota in the three categories. Harrison Bader is the leader in RBI with 12, and Ty France has a team-high .314 on-base percentage. Minnesota is batting .211 with a .338 slugging percentage. On Tuesday, Minnesota will send Bailey Ober to the mound. The right-hander is 1-1 with a 6.16 ERA, 17 Ks, and 6 BBs.

Chicago will win on the road Tuesday when visiting Minnesota, with the play here is OVER. The OVER has cashed in three of Chicago's last five. Both teams will have starting pitchers on the mound who struggled last time out. Chicago starter Davis Martin is coming off a poor outing in which the right-hander allowed four runs on four hits across 5.1 innings. Minnesota starter Bailey Ober was hit hard last time out, allowing three runs on five hits across 6.1 innings. Final Score Prediction: Chicago White Sox win but our best play is OVER 7-5.