White Sox vs Royals Picks and Prediction – 5/5/2025

By: David Anicetti |

Last Updated: 05/04/2025 at 6:52 PM ET

Chicago White Sox at Kansas City Royals 05/05/25 - MLB Picks & Predictions
Game Start: 5/5/2025, 11:40 PM UTC
Latest Odds: KAN -251 ; O/U 8

White Sox vs Royals Prediction

The Chicago White Sox open a four-game series on the road Monday versus the Kansas City Royals. Chicago is 9-24 following its 8-3 loss to the Houston Astros on Saturday, snapping a two-game winning streak by the White Sox. Chicago will complete its three-game series with Houston on Sunday. The White Sox are last in the American League Central, 11 ½ games behind first place. Keep up to date with all the MLB action with our expert MLB picks.

Lenya Sosa is batting .252 to lead Chicago and has a team-best 29 hits. Andrew Benintendi is the leader in home runs with five, and Luis Robert Jr is the leader in RBI with 14. Miguel Vargas is the leader in on-base percentage at .315. On Monday, the Chicago White Sox will send Shane Smith to the mound. The right-hander is 1-1 with a 2.23 ERA, 26 Ks, and 12 BBs.

The Kansas City Royals improved to 18-16 following Saturday’s 4-0 victory over the Baltimore Orioles. Kris Bubic pitched five innings of shutout baseball despite a rain delay early in the game. Kansas City has won four of the last five and will complete its three-game series with Baltimore on Sunday. The Royals are third in the American League Central, three games behind first place. 

Maikel Garcia is batting .307 to lead Kansas City. Vinnie Pasquantino is the leader in home runs with five and RBI with 21. Bobby Witt Jr is the leader in hits with 39 and on-base percentage at .378. Kansas City is batting .231 with a .338 slugging percentage. On Monday, Kansas City will send Cole Ragans to the mound. The left-hander is 1-1 with a 4.40 ERA, 46 Ks, and 9 BBs.

White Sox vs Royals Pick Analysis

Chicago has started poorly this season but will face a Kansas City starting pitcher who has struggled of late. Chicago starter Shane Smith has had two consecutive strong outings, allowing two runs on 10 hits across 10 innings. Kansas City starter Cole Ragans has been hit hard in two consecutive outings, allowing nine runs on nine hits across seven innings. Final Score Prediction: Chicago White Sox win 5-3.

Our Free MLB Pick for Kansas City Royals vs Chicago White Sox

Chicago White Sox +231