White Sox vs Astros Picks and Prediction – 6/12/2025

On Wednesday, the Chicago White Sox (22-44) face off against the Houston Astros (36-29) at Daikin Park in Houston, Texas. Keep up to date with all the MLB action, with our expert MLB picks.

Houston comes into this matchup on a one-game losing streak, but has won three of their last five games prior to their series opener against Chicago. In their recent 4-2 defeat against Cleveland, Cam Smith managed to drive in two runs for the Astros, going 1-for-4 at the plate. When it comes to power hitting this season, Isaac Paredes currently tops the team’s home run leaderboard, having hit fourteen so far. Following him are Jose Altuve and Jeremy Peña, each of whom have contributed nine homers, tying them for second place on the squad. Isaac Paredes is not only leading Houston in home runs but also in runs batted in, amassing a team-high thirty-eight RBIs to this point. On the batting average front, Jeremy Peña stands out, batting an impressive .316 to lead the team in that statistical category. Looking at recent performances, the Astros have averaged 3.8 runs scored over their last five games. This offensive output has helped them move two and a half games ahead of Seattle, placing them at the top of the AL West standings. Now in control of their division, Houston will be looking to maintain momentum and secure as many victories as possible to strengthen their lead. So far this season, the Astros are averaging about four runs per game overall.

Chicago enters this game on a one-game losing streak, but has won three of their last five games prior to their series opener against Houston. During their 7-5 defeat against the Kansas City Royals, Miguel Vargas stood out for the White Sox by going 1-for-3 at the plate, blasting a home run, scoring a run, and driving in three RBIs. So far this season, Vargas has emerged as Chicago’s top power threat, leading the team with nine home runs. Andrew Benintendi follows him on the team leaderboard, having recorded six home runs to this point in the year. Vargas doesn't just lead the White Sox in home runs—he’s also their top run producer, collecting a team-high 29 RBIs through the season. In terms of batting average, Lenyn Sosa has been the club’s most consistent hitter, maintaining a solid .274 mark. Over their last five games, the White Sox have managed to score an average of 4.6 runs per contest, but despite this modest upswing, they remain at the bottom of the AL Central standings. With little hope for a turnaround this season, Chicago is focused on picking up any momentum they can as they prepare to face the Astros in Houston. On the year as a whole, the team is averaging 3.5 runs per game, reflecting their struggles to consistently put runs on the board.

The White Sox have really struggled when playing away from home this season, managing to win just six of their 32 road games so far—a record that highlights their difficulties on the road. In contrast, the Astros have been extremely strong when playing in their own ballpark, making them a formidable opponent for any visiting team. Houston will aim to build on their home field advantage. For this matchup, the White Sox will send Sean Burke to the mound. So far this season, Burke holds a 3-6 win-loss record with a 4.03 ERA, indicating some inconsistency in his performances. Opposing him for the Astros will be Ryan Gusto, who has also faced his share of ups and downs with a 3-3 record and a 4.78 ERA this year. Final Score Prediction, Houston Astros win 5-4.