White Sox vs Astros Picks and Prediction – 6/11/2025

The Chicago White Sox, sitting at a brutal 22-44 and just 6-26 on the road, head to Daikin Park to face the red-hot Houston Astros (36-29, 22-12 home) on June 10 at 6:10 PM EST. Shane Smith takes the mound for the White Sox with a sharp 2.45 ERA, while Lance McCullers Jr. counters for Houston with a 4.44 ERA in limited innings. Chicago dropped a 7-5 decision to Kansas City last game, while Houston fell to Cleveland 4-2. Elevate your MLB game with our top-notch MLB picks.

Chicago has had a small recent surge, winning three of five, but they’re still in a deep hole. The loss to Kansas City came after a pair of solid wins, including a 7-2 effort behind clutch hitting. However, the White Sox offense remains a problem, averaging just .223 at the plate and ranking low across the board in runs (233), OBP (.296), and slugging (.345). Miguel Vargas leads with 9 homers and 29 RBIs, while Lenyn Sosa had been hitting .274 before hitting the IL.

On the hill, Chicago hasn’t been terrible - the team ERA sits at 4.12 with a 1.37 WHIP. Shane Smith has been one of the few bright spots, holding opponents to a .250 average over 62.1 innings with 60 strikeouts and just 4 homers allowed. Injuries are stacking up though, with Sosa, Scholtens, Gilbert, and Cannon all sidelined. The bullpen has been shaky, and the rotation lacks consistency behind Smith.

Houston comes in after a 3-2 road trip and will look to bounce back after losing to Cleveland. Before that, the Astros were rolling with three straight wins, including a dominant 8-2 showing over Pittsburgh. Offensively, this group is much deeper, hitting .250 as a team with 261 runs scored and 65 homers. Isaac Paredes is the power guy (14 HR, 38 RBI), while Jeremy Pena is tearing it up with a .316 average and .373 OBP.

On the mound, Houston is better overall with a 3.52 ERA and 1.16 WHIP. Despite a shaky ERA, McCullers Jr. brings strikeout stuff with 33 K’s in just 24.1 innings. The bullpen has been reliable, and the Astros allow just a .220 average to opponents. The defense limits damage, and this team rarely beats itself. Injuries exist, but haven’t slowed down this home-heavy squad.

This is a mismatch on paper and on the mound. The Astros are simply better in every major category—batting average, ERA, WHIP, home record, and OBP. Shane Smith’s been solid, but the White Sox offense won’t give him enough support to beat a Houston team that’s slugging and defending at a much higher level. Final Score Prediction: Houston Astros win 6-2.