White Sox vs Tigers Picks and Prediction – 4/6/2025

By: David Anicetti |

Last Updated: 04/05/2025 at 7:32 PM ET

Chicago White Sox at Detroit Tigers 04/06/25 - MLB Picks & Predictions
Game Start: 4/6/2025, 5:40 PM UTC
Latest Odds: DET -220 ; O/U 7.5

White Sox vs Tigers Prediction

The Chicago White Sox conclude a three-game series on the road Sunday versus the Detroit Tigers. Chicago is 2-5 and last in the American League Central, but just one game behind three co-leaders. The White Sox lost the opening game of the series to Detroit 7-4. Chicago has lost three straight and five of the last six. The only two wins thus far have been over the Angels and Twins. Keep up to date with all the MLB action with our MLB picks.

Andres Benintendi is batting .320 with two home runs, six RBI, eight hits, and an on-base percentage of .370 to lead Chicago in each of the five categories. Chicago has a team batting average of .212 and a slugging percentage of .372. On Sunday, the Chicago White Sox will send Martin Perez to the mound. The left-hander is 1-0 with a 0.00 ERA, 9 Ks, and 3 BBs.

With Friday’s three-run win, Detroit improved to 3-4 and is in a three-way tie with Cleveland and Kansas City at the top of the AL Central. Kerry Carpenter hit a pair of home runs to help lead Detroit to its victory. Detroit has won 14 of its last 17 home openers. The Tigers began the season with three consecutive losses but have since won three of the last four.

Riley Greene is batting .344 with three home runs and 11 hits to lead the Tigers in the three categories. Kerry Carpenter is the leader in RBI with six, and Spencer Torkelson has a team-best .469 on-base percentage. Detroit has a team batting average of .269 and a slugging percentage of .454. On Sunday, the Detroit Tigers will send Jackson Jobe to the mound. The right-hander is 0-0 with a 6.75 ERA, 3 Ks, and 4 BBs.

White Sox vs Tigers Pick Analysis

Chicago has struggled to start the season but will have a strong starting pitcher on the mound and will win on Sunday. Chicago starter Martin Perez pitched exceptionally well in his season opener, allowing no runs on no hits across 6 innings with nine strikeouts and three walks. Detroit starter Jackson Jobe was hit hard in his opener, allowing three runs on three hits across just four innings. Final Score Prediction, Chicago White Sox win 5-2.

Our Free MLB Pick for Detroit Tigers vs Chicago White Sox

Chicago White Sox +200