White Sox vs Guardians Picks and Prediction – 4/10/2025

The Chicago White Sox continue a road trip Thursday with a game in Cleveland against the Guardians. Chicago is one of the worst teams in baseball again this season with just two wins through 10 games played running a long losing streak after their loss in Game 1 of this series. Offensively Chicago has been terrible this season with a .199 team batting average as the White Sox scores 32 runs on 62 little hits here at the Chicago pitching has been just as bad with a 3.75 team ERA. Stay in the action with our MLB Picks.

Andrew Benintendi leads the Chicago offense this season with a .290 batting average and is 1 of two players on the roster with two home runs to go along with the team leading six RBI's. Brooks Baldwin has a .250 batting average and Korey Lee has a .385 batting average but has played just eight times this season.

The Cleveland Guardians stay on their home field Thursday two games below .500 on the year having won two of the last five following their win in Game 1 of this set to end a 2 game skid. Offensively Cleveland has been mediocre with a .211 batting average as the Guardians have scored 35 runs on 60-7 hits. The Cleveland power has shined however with 13 home runs and a .375 teams slugging percentage.

Steven Kwan is the offensive leader this season for Cleveland with a .316 batting average. Carlos Santana has a .281 batting average and Gabriel Arias has a .226 batting average. Jose Ramirez supplied  the power for Cleveland this season leading the team with four home runs overall. Kyle Manzanedo has posted a team leading nine home runs in 10 games play.

Cleveland is far and away the better team here as Chicago has already fallen to one of the worst teams in baseball. Take Cleveland to dominate this game start to finish against a bad White Sox team. The Guardians will do the work in this game leading to the home win and cover. Final Score Prediction, Cleveland Guardians win and cover 6-1.