White Sox vs Guardians Picks and Prediction – 4/8/2025

The Chicago White Sox open a three-game series on the road Tuesday versus the Cleveland Guardians. Chicago is 2-7 and last in the American League Central, three games behind the first-place Detroit Tigers. Chicago lost to the Detroit Tigers 4-3 on Sunday. Chicago has lost each of the last five. The White Sox were off on Monday before heading to Cleveland for Tuesday’s game. Keep up to date with all the MLB action with our expert MLB picks.

Andrew Benintendi is batting .290 with two home runs, six RBI, nine hits, and an on-base percentage of .333 to lead Chicago in each of the five categories. Chicago has a team batting average of .211 and a slugging percentage of .344. On Tuesday, the Chicago White Sox will send Shane Smith to the mound. The right-hander is 0-0 with a 3.18 ERA, 3 Ks, and 4 BBs.

The Cleveland Indians look to snap a two-game losing streak with a victory at home on Tuesday when opening their three-game series with Chicago. Cleveland is 3-6 and tied for third in the AL Central, two games behind first-place Detroit. Cleveland lost to the Los Angeles Angels 6-2 on Sunday. The Indians have lost two straight and five of the last six.

Steven Kwan is batting .353 with 12 hits to lead Cleveland in both. Jose Ramirez is the leader in home runs with four and in on-base percentage at .438. Kyle Manzardo is the leader in RBI with nine. Cleveland has a batting average of .221 and a slugging percentage of .400. On Tuesday, Cleveland will send Ben Lively to the mound. The right-hander is 0-1 with a 6.75 ERA, 7 Ks, and 2 BBs.

Chicago has lost five straight, but the White Sox will have a starter on the mound who has performed better thus far than Cleveland’s. Cleveland has lost five of its last six. Chicago starter Shane Smith gave up two runs on two hits across 5.2 innings in his only appearance of the season. Cleveland starter Ben Lively has been hit hard in both appearances, allowing seven runs across 9.1 innings. Final Score Prediction, Chicago White Sox win 5-2.