White Sox vs Cubs Picks and Prediction – 5/18/2025

The Chicago White Sox complete a three-game series on the road Sunday versus the Chicago Cubs. The White Sox dropped to 14-31 following Friday’s 13-3 loss to the Cubs in the opening game of the series. The White Sox have lost two straight and sit last in the American League Central, 16 games behind the first-place Detroit Tigers. Keep up to date with all the MLB action with our MLB predictions.

Lenya Sosa is .267 to lead Chicago and has a team high of 40 hits. Andrew Benintendi is the leader in home runs with five, and Miguel Vargas is the leader in RBI with 19, and on-base percentage at .326. The White Sox are batting .217 with a .329 slugging percentage. On Sunday, the White Sox will send Jonathan Cannon to the mound. The right-hander is 2-4 with a 3.60 ERA, 39 Ks, and 17 BBs.

The Chicago Cubs improved to 26-19 following Friday’s 10-run victory. Pete Crow-Armstrong hit a home run and knocked in a career-high six runs for the Cubs. Chicago has won three of the last four. The Cubs are second in runs scored and 18th and ERA at 4.00. The Cubs lead the National League Central by one game over the second-place St Louis Cardinals.

Pete Crow-Armstrong is batting .282 with 12 home runs and 49 hits to lead Chicago in the three categories. Seiya Suzuki is the leader in RBI with 37, and Kyle Tucker is the leader in on-base percentage at .372. The Cubs are batting .253 with a .440 slugging percentage. On Sunday, the Cubs will send Colin Rea to the mound. The right-hander is 3-0 with a 2.48 ERA, 29 Ks, and 9 BBs.

The Cubs will win this Crosstown Classic on Sunday, but the play here is UNDER. The UNDER has cashed in five of the White Sox’ last six and seven of their last nine played on the road. White Sox starter Jonathan Cannon has had three consecutive strong outings, allowing four runs on 22 hits across 18 innings. Cubs’ starter Colin Rea has pitched well in four of the last five outings and on the season has a solid 2.48 ERA. Final Score Prediction: Chicago Cubs win but our best play is UNDER 5-2.